Can Juvederm Boost Long Term Collagen?

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Injectable wrinkle fillers like Juvederm and Restylane provide an increasingly popular aesthetic way to smooth facial lines and restore lost facial volume. Many patients choose hyaluronic acid (HA) fillers to rejuvenate skin damaged by sun exposure, aging, or genetics to look and feel younger. While the plumping effects of HA fillers are well-established, new research evidence suggests these products also spur new collagen formation for more sustained, natural-looking improvements over time.

How Does Juvederm Work For Facial Rejuvenation?

Juvéderm, a popular injectable dermal filler, works for facial rejuvenation primarily through its key ingredient, hyaluronic acid (HA). Here’s how Juvéderm achieves facial rejuvenation:

  1. Hyaluronic Acid Content: Juvéderm is a clear gel containing hyaluronic acid, a natural sugar molecule found in the skin and joints. Hyaluronic acid has a unique ability to bind with water, providing hydration to the skin.
  2. Volume Restoration: As we age, the skin loses volume and elasticity, leading to the formation of wrinkles and folds. Juvéderm is injected beneath the skin to replace lost volume, effectively filling in wrinkles, lines, and areas of facial hollowing.
  3. Hydration: The water-binding properties of hyaluronic acid contribute to skin hydration. This not only helps in the immediate plumping of the treated areas but also enhances overall skin quality and texture.
  4. Collagen Stimulation: Recent studies suggest that HA fillers like Juvéderm can stimulate neocollagenesis (the production of new collagen fibers). Collagen is a crucial protein for maintaining skin structure and firmness. Juvéderm may trigger fibroblasts, the collagen-producing cells, to increase collagen production.
  5. Mechanical Tension: The injection of Juvéderm creates a physical expansion effect. Existing collagen fibers are stretched, imposing mechanical tension on surrounding fibroblasts. This mechanical tension can stimulate fibroblasts to produce more collagen, contributing to skin tightening and rejuvenation.
  6. Chemical Effects: The chemical cross-linking bonds in Juvéderm, which stabilize the filler, also play a role in increased stability, allowing for improved water binding and skin hydration. Better hydration supports cellular functions and aids in tissue repair.
  7. Long-Term Effects: Juvéderm’s effects are not only immediate but can also have extended benefits. Studies have shown persistent correction and improved cosmetic results even years after the initial injections. This suggests ongoing collagen formation and enhanced skin quality.
  8. Wide Range of Applications: Juvéderm can be used for various facial rejuvenation purposes, including filling lines and wrinkles, enhancing lip volume, restoring facial contours, and improving overall skin texture.

In summary, Juvéderm works for facial rejuvenation by restoring lost volume, providing hydration, and potentially stimulating the production of new collagen. The multifaceted approach of Juvéderm makes it a versatile and effective option for addressing signs of aging and achieving a more youthful appearance.

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What Did The Research Discover?

Two Research Studies

Two separate research studies found that injections of hyaluronic acid (HA) fillers can lead to the creation of new collagen fibers at the treated areas, a process they called “neocollagenesis.” They tested this by comparing treated and non-treated areas using specialized imaging and protein analysis, showing significant collagen and tissue rebuilding with HA fillers.

While the filler directly adds volume to reduce wrinkles, the awakened collagen activity offers a way for long-lasting correction as the new collagen integrates with the surrounding skin.

Real World Aesthetic Results

Dr. Cathy Koger observed this phenomenon in a patient who had a single Restylane treatment. The patient, a 50-year-old woman, received Restylane in 2005 for her nasolabial folds. Photos taken three years after in 2008 and eight years later in 2013 revealed persistent correction that exceeded the expected duration of the product.

Dr. Koger suggests that the formation of new collagen, known as de novo collagen formation, likely contributed to these impressive and longer-lasting results. The positive response continued even after the original injections were absorbed and broken down by enzymes.

Mechanisms Stimulating Collagen Rebuilding

But how do HA fillers spark new collagen manufacture exactly? Dr. Koger summarizes two fundamental mechanisms:

1. Physical Expansion: “Existing collagen fibers are stretched by HA injection, which imposes mechanical tension on surrounding fibroblasts [collagen-making skin cells]. Therefore stimulating them to increase production.”

2. Chemical Effects: Chemical cross-linking bonds that stabilize HA fillers also cause “increased stability allowing for improved water binding and skin hydration.” Better hydration assists tissue in repairing cellular functions.

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Future Implications for Aesthetic Injectables

Recognizing HA fillers spur collagen renewal opens new possibilities for aesthetic care. Beyond filling lines and wrinkles through direct injection, stimulating fibroblasts may assist:

  • Improving skin tone/texture
  • Tightening sagging areas through strengthened native support
  • Restoring facial definition as new collagen integrates long-term

The phenomenon of neocollagenesis proves HA fillers exert effects extending far beyond their visible placement to fix isolated problems. Unleashing the skin’s latent regenerative capacity creates ripple benefits, for facial rejuvenation. With further research into optimal placement and dosing, injectors can leverage filler collagen activation for unprecedented facial renewal.


Juvederm, a popular hyaluronic acid (HA) filler, offers effective facial rejuvenation through its multifaceted approach. By restoring lost volume, providing hydration, and potentially stimulating new collagen production, Juvederm addresses signs of aging for a more youthful appearance. Research indicates that HA fillers, including Juvederm, can lead to “neocollagenesis,” the creation of new collagen fibers, contributing to long-lasting benefits beyond immediate correction.

Real-world observations, such as Dr. Cathy Koger’s patient case, demonstrate the persistent correction and improved cosmetic results even years after the initial injections. This phenomenon involves physical expansion and chemical effects, where HA fillers stimulate fibroblasts, leading to increased collagen production and improved skin hydration.

This discovery of neocollagenesis opens new possibilities for injectables, suggesting potential benefits beyond wrinkle filling. Improving skin tone, tightening sagging areas, and restoring facial definition through stimulated collagen production represent a significant advancement in aesthetic care.

As we delve into the future implications of injectables, recognizing their role in collagen renewal highlights the transformative potential for facial rejuvenation. Further research into optimal placement and dosing holds promise for leveraging filler collagen activation, ushering in an era of unprecedented facial renewal and aesthetic possibilities.

About Marielaina Perrone, DDS

Cosmetic Dentist Marielaina Perrone DDS

Dr. Marielaina Perrone is a highly respected and experienced dentist in Henderson, Nevada. With over two decades of expertise in providing quality dental care to her patients. She graduated from Stony Brook University School Of Dental Medicine. She has completed advanced training in cosmetic dentistry, implant dentistry, and treatment of advanced periodontal disease.

Dr. Perrone remains committed to staying up-to-date with the latest advancements in dentistry and continuing education to ensure she provides the best possible care for her patients in Las Vegas and Henderson NV.

Dr. Perrone takes a patient-centered approach and believes in personalized treatment plans tailored to each individual’s unique needs and preferences. Her gentle and compassionate demeanor creates a comfortable and relaxed atmosphere for patients during their dental appointments.

Aside from dentistry, Dr. Perrone enjoys spending time with her family, traveling, and cooking. She also volunteers her time and expertise to various charitable organizations in her community.


  1. Bobby McRoy on February 3, 2024 at 11:47 pm

    Dr. Perrone……Is one of the most personable individuals in her field of experience over 20 years service. A true professional of dentistry, in her field. She’s also is an activist for childner who are hospitalized regardless of all ethnicity. Ashley Strong foundation! I am very proud and pleased to know her on how, she will make your teeth healthy, is her first priority. Dr. Perrone is a phenomenal and a resilient Dentist to get it right. No doubt.

    Here office team members and her specialist for their service is absolutely impeccable. One love

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