Injectable wrinkle fillers like Juvederm and Restylane provide an increasingly popular aesthetic way to smooth facial lines and restore lost facial volume. Many patients choose hyaluronic acid (HA) fillers to rejuvenate skin damaged by sun exposure, aging, or genetics to look and feel younger. While the plumping effects of HA fillers are well-established, new research evidence suggests these products also spur new collagen formation for more sustained, natural-looking improvements over time.
Two separate research studies found that injections of hyaluronic acid (HA) fillers can lead to the creation of new collagen fibers at the treated areas, a process they called “neocollagenesis.” They tested this by comparing treated and non-treated areas using specialized imaging and protein analysis, showing significant collagen and tissue rebuilding with HA fillers.
While the filler directly adds volume to reduce wrinkles, the awakened collagen activity offers a way for long-lasting correction as the new collagen integrates with the surrounding skin.
Real World Aesthetic Results
Dr. Cathy Koger observed this phenomenon in a patient who had a single Restylane treatment. The patient, a 50-year-old woman, received Restylane in 2005 for her nasolabial folds. Photos taken three years after in 2008 and eight years later in 2013 revealed persistent correction that exceeded the expected duration of the product.
Dr. Koger suggests that the formation of new collagen, known as de novo collagen formation, likely contributed to these impressive and longer-lasting results. The positive response continued even after the original injections were absorbed and broken down by enzymes.
Mechanisms Stimulating Collagen Rebuilding
But how do HA fillers spark new collagen manufacture exactly? Dr. Koger summarizes two fundamental mechanisms:
1. Physical Expansion: “Existing collagen fibers are stretched by HA injection, which imposes mechanical tension on surrounding fibroblasts [collagen-making skin cells]. Therefore stimulating them to increase production.”
2. Chemical Effects: Chemical cross-linking bonds that stabilize HA fillers also cause “increased stability allowing for improved water binding and skin hydration.” Better hydration assists tissue in repairing cellular functions.
Future Implications for Aesthetic Injectables
Recognizing HA fillers spur collagen renewal opens new possibilities for aesthetic care. Beyond filling lines and wrinkles through direct injection, stimulating fibroblasts may assist:
- Improving skin tone/texture
- Tightening sagging areas through strengthened native support
- Restoring facial definition as new collagen integrates long-term
The phenomenon of neocollagenesis proves HA fillers exert effects extending far beyond their visible placement to fix isolated problems. Unleashing the skin’s latent regenerative capacity creates ripple benefits, for facial rejuvenation. With further research into optimal placement and dosing, injectors can leverage filler collagen activation for unprecedented facial renewal.
Juvederm, a popular hyaluronic acid (HA) filler, offers effective facial rejuvenation through its multifaceted approach. By restoring lost volume, providing hydration, and potentially stimulating new collagen production, Juvederm addresses signs of aging for a more youthful appearance. Research indicates that HA fillers, including Juvederm, can lead to “neocollagenesis,” the creation of new collagen fibers, contributing to long-lasting benefits beyond immediate correction.
Real-world observations, such as Dr. Cathy Koger’s patient case, demonstrate the persistent correction and improved cosmetic results even years after the initial injections. This phenomenon involves physical expansion and chemical effects, where HA fillers stimulate fibroblasts, leading to increased collagen production and improved skin hydration.
This discovery of neocollagenesis opens new possibilities for injectables, suggesting potential benefits beyond wrinkle filling. Improving skin tone, tightening sagging areas, and restoring facial definition through stimulated collagen production represent a significant advancement in aesthetic care.
As we delve into the future implications of injectables, recognizing their role in collagen renewal highlights the transformative potential for facial rejuvenation. Further research into optimal placement and dosing holds promise for leveraging filler collagen activation, ushering in an era of unprecedented facial renewal and aesthetic possibilities.
About Marielaina Perrone, DDS
Dr. Marielaina Perrone is a highly respected and experienced dentist in Henderson, Nevada. With over two decades of expertise in providing quality dental care to her patients. She graduated from Stony Brook University School Of Dental Medicine. She has completed advanced training in cosmetic dentistry, implant dentistry, and treatment of advanced periodontal disease.
Dr. Perrone remains committed to staying up-to-date with the latest advancements in dentistry and continuing education to ensure she provides the best possible care for her patients in Las Vegas and Henderson NV.
Dr. Perrone takes a patient-centered approach and believes in personalized treatment plans tailored to each individual’s unique needs and preferences. Her gentle and compassionate demeanor creates a comfortable and relaxed atmosphere for patients during their dental appointments.
Aside from dentistry, Dr. Perrone enjoys spending time with her family, traveling, and cooking. She also volunteers her time and expertise to various charitable organizations in her community.