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Dentistry is not a one size fits all type of medicine. Dentistry is a very personalized treatment for our dental health. This includes treatment and management of periodontal disease. DNA testing is all the craze with companies like 23andMe. But did you know you can use DNA testing for oral diseases as well? The company is called OralDNA and they have developed three separate testing methods. These include early warning and detection for periodontal disease, personalized treatment for periodontal disease, and checking if you have increased risk of developing HPV related oral cancers.

OralDNA Approach To Periodontal Disease

OralDNA Henderson NV Marielaina Perrone DDS-OralDNA MyPerioPath testing. Oral DNA MyPerioPath is a diagnostic tool for the detection of the type of oral pathogens present in your mouth that can cause periodontal disease. By using this test your dentist can create a personalized care to deal with the pathogens causing the issues in your mouth. There is also evidence that knowing what oral pathogens are present can also determine a patients increased risk of developing Diabetes, cardiovascular disease, alzheimer’s disease, possible stroke, and if pregnant, risk of birth complications. Clinical studies are increasingly linking oral bacteria with systemic disease. For example, inflammation is a major factor in both periodontal disease and heart disease. recent studies have found that a high dose of a common cholesterol medication (atorvastatin) can prevent inflammation from both periodontal inflammation as well as cardiovascular inflammation. Statin family of medicines have other side effects as well not always that good. But this adds to the education that there is a connection between periodontal disease and heart disease.

The Oral DNA MyPerioPath test can determine if the following pathogens are present and in what levels:

  • (Aa) Aggregatibacter actinomycetemcomitans
  • (Pg) Porphyromonas gingivalis
  • (Tf) Tannerella forsythia
  • (Td) Treponema denticola
  • (En) Eubacterium nodatum
  • (Fn) Fusobacterium nucleatum/periodonticum
  • (Pi) Prevotella intermedia
  • (Cr) Campylobacter rectus
  • (Pm) Peptostreptococcus (Micromonas) micros
  • (Ec) Eikenella corrodens
  • (Cs) Capnocytophaga species (gingavalis, ochracea, sputigena)

The Oral DNA MyPerioPath testing should be done on an annual basis. Once at start of periodontal disease treatment and then one at end of first year to track progress of personalized treatment and if any changes need to be made to improve periodontal disease state. Oral DNA MyPerioPath is a valuable tool that can allow you and your dentist to measure success and track progress for a more personalized periodontal disease therapy.

Oral DNA MyPerioPath combined With MyPerioID. The Oral DNA MyPerioID test assesses a persons inherited genetic risk to developing periodontal disease as well as other systemic diseases as mentioned above. Combining the 2 tests can give greater control to personalized periodontal disease care and give a fuller picture to you and your dentist. Can also help determine which patients are at increased risk for more severe periodontal disease infections due to an exaggerated immunity response.

Oral DNA OraRisk HPV Test. This test can determine if there is increased risk for HPV related oral cancer. Human papillomavirus (HPV) is one of the most common virus groups inoral DNA Periodontal Disease las vegas Marielaina Perrone DDS the world (and is linked to the HPV virus in the mouth). Specific types of oral HPV are now considered to be separate and serious risk factors for developing oral cancers. Early detection and identification of the presence or absence of oral HPV is important, as early oral HPV infections do not typically cause any clinical signs or symptoms.

-Oral DNA OraRisk HPV Complete Genotyping Test. This HPV test gives data to your dentist or doctor to establish if there is increased risk for oral cancer and have the ability to make proper referral for further treatment.  Oral DNA OraRisk HPV complete genotyping has the ability to identify a total of 51 different types of oral HPV.

Oral Pathogens Associated With Periodontal Disease

Periodontal researchers have uncovered more than 350 different species of microorganisms that are present in a normal, healthy person’s mouth. Fewer than 5% of these species are linked to periodontal disease. It has also proven that these bacteria that cause periodontal disease, can be shared with your partner or loved ones.

Generally healthy and disease causing bacteria are usually placed into two distinct bacteria categories:

Gram positive aerobic bacteria. These are harmless or helpful bacteria in the mouth.

Gram negative anaerobic bacteria. These are the bacteria known to be related to periodontal disease. When periodontal disease develops, the bacterial balance in the mouth shifts over to gram negative anaerobic bacteria. Inflammation and injury cannot develop without these bacteria flourishing in the mouth.

Common bacteria involved in periodontal disease include:

Actinobacillus actinomycetemcomitans (Ag) and Porphyromonas gingivalis (Pg). These two bacteria appear to be particularly likely to cause aggressive periodontal disease. Both P. gingivalis and A. actinomycetemcomitans, along with multiple deep pockets in the gum, show increased resistance to standard dental treatments for periodontal disease. The presence of P. gingivalis may even have 2x the risk for serious periodontal disease. P. gingivalis produces enzymes, such as one called arginine-specific cysteine proteinase, that has been linked to a disruption of the immune system and lead to subsequent periodontal connective tissue destruction.

Bacteroides forsythus is also strongly linked to periodontal disease.

Other bacteria associated with periodontal disease are Treponema denticolaT. socranskii, and P. intermedia. These bacteria, together with P. gingivalis, are frequently present at the same sites, and are associated with deep periodontal pockets.

Some bacteria are related just to gingivitis, but not development of plaque. They include various streptococcal species.

As you can see there are a variety of bacteria that are linked to periodontal disease. The MyPerioPath testing can isolate the bacteria causing the issues for you. Your dentist can use antibiotic therapy and rinses to personalize care for your particular case.

How does OralDNA testing help to individualize periodontal disease treatment?

The ability to know the bacteria that is causing the issue allows treatment to target that bacteria. Periodontal disease treatment can include the following:

Scaling And Root Planing (S&RP). Also called a “deep” cleaning. The initial goal of any periodontal disease treatment must be the removal of plaque and tartar buildup that is causing irritation and inflammation development. The scaling and root planing procedure is done with this in mind as well as to allow for healing and reattachment of gingival fibers to the tooth. This healing can hopefully reduce size of periodontal pocketing (normal about 3mm).

Antibitoics Application. This can include administering this via a pill orally or placed into local areas that need help. Arestin is an antibiotic that can be placed directly into a periodontal pocket and give local therapy. This is important as it reaches places your dentist cannot but it also does not have the side effects of a systemic pill. The use of antibiotics will help control the overgrowth of the “bad” bacteria that is flourishing due to periodontal disease.

-Dental Hygiene Instructions. This is a staple of any periodontal disease treatment. This disease will be an ongoing problem that needs maintenance to stave it off. This includes proper brushing, flossing, and rinsing. Your dentist may even prescribe a prescription oral rinse to control bacteria or even Periogen. Periogen is an oral rinse that has been shown to help dissolve tartar between visits to the dentist. By lowering amount of tartar in the mouth you are hopefully also lowering the irritatation and inflammatory response.

Periodontal Disease Treatment With Oral DNA Testing Conclusion

DNA testing has been a great tool in many facets of society. It can also be one for dentistry thanks to OralDNA. There is an increased cost for this type of testing but it comes with great benefits in controlling a disease that can be difficult to manage. Any advantage will save you time and discomfort over time during treatment as well as possible tooth loss and systemic health maintenance. Periodontal disease linked to heart disease (as well as other diseases) should be motivation enough to get this under control. See your dentist at the first signs of periodontal disease and get your health back on track.


For most of the world the mere mention of the word cancer is frightening. Everyone’s lives have been touched in some way by this dreaded disease. However, with today’s medical advancements many different types of cancer of very treatable and very curable. Unfortunately, oral cancer is not one of those types of cancer. In fact, oral cancer kills one person per hour every day of the year in the United States alone. Another issue with oral cancer is it is often not detected until the later stages when it is too late for treatment.

What Is Oral Cancer?

Oral cancer includes any cancer that begins and develops in your mouth. This can mean the throat, cheeks, tongue, hard and soft palates, floor of the mouth, or lips. Oral cancer usually begins as a sore in the mouth that does not heal. Unfortunately, many assume it is just a canker sore or a pizza burn and ignore it. This usually leads to a much later detection of the disease. The majority of oral cancer is classified as squamous cell carcinoma, which attacks epithelial cells.

Males are at a higher risk of developing oral cancer. They run 2 times (2x) the risk as females do of developing oral cancer. That may be because many of the top causes of oral cancer, such as smoking, are more widely practiced by men than women. As for age, people who are middle-aged and older are most likely to develop the disease.

Oral cancer kills over 8,000 people every year in the United States. Approximately 43,000 are newly diagnosed each year, but many others go into remission only to have the cancer come back a few years later. The oral cancer survival rate is 57 percent, and this has actually improved over the past decade (used to be 50% survival rate) as people become more vigilant about getting screened.

A disturbing trend is that an increasing number of oral cancer cases are being caused by HPV16 (a type of Human Papilloma Virus) that effects the mucus membranes and skin. It tends to affect the back of the mouth, including the oropharynx, the tonsils, and the base of the tongue.Unfortunately, since these types of cancer are in the back of the mouth, the color changes and lesions that often signal the presence of oral cancer can be more easily overlooked by patients. They may not know that their mouth has undergone any chance and not seek professional care.

Oral cancer has a high risk of recurring for the first 10 years after diagnosis. Patients are up to 20 times (20x) as likely to get cancer again as those who have not been diagnosed with oral cancer.

Oral Cancer Risk Factors

There are many risk factors and these can include:

-Smoking (Tobacco use).

-Excessive Drinking Of Alcohol.

-Smog.

-Herpes Infections.

-Age.

Periodontal Disease.

-Poor Nutrition.

Oral Cancer Signs And Symptoms

The most commons signs and symptoms of oral cancer include:

-Oral sores lasting for 2 weeks or more without healing.

-Facia or oral numbness.

-Unexplained facial or oral pain.

-Unexplained lingering sore throat.

-Changes in your voice (increased hoarseness).

-Ear pain.

-Unexplained weight loss.

-Frequent oral bleeding with no apparent cause.

-White or red patches in the mouth.

-Crusty lesions inside or outside the mouth.

Oral Cancer Screening By Your Dentist

Your dentist should screen for oral cancer during routine dental examinations at least twice a year. A manual and visual examination is necessary. He or she feels for lumps or irregular tissue changes in your neck, head, cheeks and oral cavity, and thoroughly examines the soft tissues in your mouth, specifically looking for any sores or discolored tissues. The use of the Velscope oral cancer screening system has been proven to diagnose precancerous as well as cancerous changes in the tissue as early as possible to give you the best chance for recovery and survival from oral cancer.

Treatment of Oral Cancer

If during your dental examination your dentist finds anything suspicious they will recommend that you have a biopsy performed of that area. The biopsy of the lesion will be used to confirm the diagnosis of cancer. If it is confirmed that you do indeed have oral cancer you will probably be referred to an oral surgeon for removal of the tumors. Radiation or chemotherapy may be also used in the course of your treatment.

Oral Cancer Conclusion

If you have any concerns about your oral health or have any of the warning signs listed above, see your dentist immediately. As in any disease, an early diagnosis and treatment can make a huge difference. Survival rates greatly increase the earlier oral cancer is discovered and treated. So be vigilant and, even if you do not have any warning signs, visit your dentist for routine oral cancer screenings.



Cancer is never an easy disease to face. Many types of cancer are very treatable especially when diagnosed early. Oral cancer is one of those that are easily treatable in its very earliest stages. However, the prognosis changes dramatically once it progresses. Oral cancer is any cancer of the mouth and the pharynx. The most common oral cancer affects the squamous cells in your mouth and can spread quite quickly. If not diagnosed and treated in its early stages, oral cancer can spread, leading to chronic pain, loss of function, irreparable facial and oral disfigurement, and even death. Oral cancer accounts for about 40,000 diagnoses per year and 8,000 deaths annually.

Causes Of Oral Cancer

Use Of Tobacco Products.

Heavy Alcohol Use.

Human Paplilloma Virus (HPV).

Excessive Exposure To Sun.

Warning Signs Of Oral Cancer

-Presence Of White Or Red Patch In The Mouth Or On The Lips.

-Persistent Mouth Sore. Any mouth sore that persists longer than 10-14 days.

-Persistent Sore Throat. Difficulty swallowing or persistent hoarseness.

-Difficulty In Chewing, swallowing, moving the jaw or tongue.

-Numbness In The Tongue.

-A Constant, Unexplained Toothache.

An Earache.

Oral Cancer Screening By Your Dentist

Your dentist should screen for oral cancer during routine dental examinations at least twice a year. A manual and visual examination is necessary. He or she feels for lumps or irregular tissue changes in your neck, head, cheeks and oral cavity, and thoroughly examines the soft tissues in your mouth, specifically looking for any sores or discolored tissues. The use of the Velscope oral cancer screening system has been proven to diagnose precancerous as well as cancerous changes in the tissue as early as possible to give you the best chance for recovery and survival from oral cancer.

Treatment of Oral Cancer

If during your dental examination your dentist finds anything suspicious they will recommend that you have a biopsy performed of that area. The biopsy of the lesion will be used to confirm the diagnosis of cancer. If it is confirmed that you do indeed have oral cancer you will probably be referred to an oral surgeon for removal of the tumors. Radiation or chemotherapy may be also used in the course of your treatment.

Oral Cancer Conclusion

If you have any concerns about your oral health or have any of the warning signs listed above, see your dentist immediately. As in any disease, an early diagnosis and treatment can make a huge difference. Survival rates greatly increase the earlier oral cancer is discovered and treated. So be vigilant and, even if you do not have any warning signs, visit your dentist for routine oral cancer screenings.